Tetrahydrofuran → 7-Hydroxychromanone

HRID 1620022

Reaktionsgleichung

Reaktionsgleichung von HRID 1620022
O[C:2]1[C:3](=[O:12])[O:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.C1C[O:16]CC1>[OH-].[Pd+2].[OH-]>[OH:16][C:7]1[CH:6]=[C:5]2[C:10]([CH2:11][CH2:2][C:3](=[O:12])[O:4]2)=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 8028TetrahydrofuranHCID 136503-Hydroxycoumarin

Produkt 1

HCID 2981307-Hydroxychromanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 9942167Palladium hydroxideKatalysator

Versuchsvorschrift

A solution of hydroxycoumarin (2.0 g, TCI) in anhydrous THF (50 ml) was added with 10% palladium hydroxide/activated carbon (1.0 g, WAKO), and stirred at room temperature for 2 hours under hydrogen atmosphere. The atmosphere was replaced with nitrogen gas, and then the insoluble matters were removed by filtration through Celite. The solvent was evaporated under reduced pressure to obtain the title compound (2.0 g).

Aufarbeitung

  1. customthe insoluble matters were removed by filtration through Celite
  2. customThe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-42b5a6e743ec43ad98e4c4167e7422da
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772327B2

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