Hydrogen chloride-ethyl acetate → HCID 178482469, Verbindung

HRID 1620468Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620468
[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[ClH:23].C(OCC)(=O)C>O1CCCC1.CO>[ClH:23].[ClH:23].[CH3:1][NH:2][C:3]1=[N:4][C:5](=[O:22])[S:6]/[C:7]/1=[CH:8]\[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1

Komponenten

4

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178482474HCID 178482474, Verbindung

Produkt 1

HCID 178482469HCID 178482469, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899815MeOH tetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of tert-butyl 4-{(Z)-[4-(methylamino)-2-oxo-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (1.27 g) in tetrahydrofuran/methanol (6 mL/6 mL) was added 4M hydrogen chloride/ethyl acetate solution (5.85 mL), and the reaction mixture was stirred at 80° C. for 2 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (1.02 g).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-3ee7f2a319124748babbb23808b54c5c
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772277B2

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