p-Toluenesulfonic acid monohydrate → 1-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde tosylate

HRID 1620492Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620492
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([CH:12]=[O:13])[CH2:8][CH2:7]1.O.[C:25]1([CH3:35])[CH:30]=[CH:29][C:28]([S:31]([OH:34])(=[O:33])=[O:32])=[CH:27][CH:26]=1>C1(C)C=CC=CC=1>[S:31]([C:28]1[CH:29]=[CH:30][C:25]([CH3:35])=[CH:26][CH:27]=1)([OH:34])(=[O:33])=[O:32].[F:23][C:2]([F:1])([F:22])[C:3]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([CH:12]=[O:13])[CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 866786631-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde

Produkt 1

HCID 866786841-[2,4-Bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde tosylateAusbeute 95,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1-[2,4-bis(trifluoromethyl)benzyl]piperidine-4-carbaldehyde (170 mg) in toluene (2 mL) was added p-toluenesulfonic acid monohydrate (95 mg), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate. The obtained solid was dried at 60° C. under reduced pressure to give the title compound (244 mg).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. customThe obtained solid was dried at 60° C. under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0a7ee7149e3d424690dc321f91ccbc96
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772277B2

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