Hydrogen chloride-ethyl acetate → HCID 178456897, Verbindung

HRID 1620499

Reaktionsgleichung

Reaktionsgleichung von HRID 1620499
[O:1]=[C:2]1[N:6]=[C:5]([NH:7][CH2:8][C:9]#[CH:10])/[C:4](=[CH:11]/[CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)/[S:3]1.[ClH:25].C(OCC)(=O)C>>[ClH:25].[ClH:25].[NH:15]1[CH2:16][CH2:17][CH:12](/[CH:11]=[C:4]2/[C:5]([NH:7][CH2:8][C:9]#[CH:10])=[N:6][C:2](=[O:1])[S:3]/2)[CH2:13][CH2:14]1

Komponenten

3

Edukt 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178456946HCID 178456946, Verbindung

Produkt 1

HCID 178456897HCID 178456897, Verbindung

Versuchsvorschrift

A mixed solution of tert-butyl 4-{(Z)-[2-oxo-4-(prop-2-yn-1-ylamino)-1,3-thiazol-5(2H)-ylidene]methyl}piperidine-1-carboxylate (14.0 g) and 4M hydrogen chloride/ethyl acetate solution (80 mL) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was washed with ethyl acetate to give the title compound (12.7 g).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. washThe residue was washed with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-70343f03bc6e4b52a2f38fb43b3958f6
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772277B2

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