Fumaric Acid → HCID 178482471, Verbindung

HRID 1620520Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620520
[F:1][C:2]([F:30])([F:29])[C:3]1[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH3:20])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1.[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35]>C(O)C>[C:31]([OH:38])(=[O:37])/[CH:32]=[CH:33]/[C:34]([OH:36])=[O:35].[F:30][C:2]([F:1])([F:29])[C:3]1[CH:24]=[C:23]([C:25]([F:27])([F:28])[F:26])[CH:22]=[CH:21][C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9](/[CH:12]=[C:13]2/[C:14]([NH:19][CH3:20])=[N:15][C:16](=[O:18])[S:17]/2)[CH2:8][CH2:7]1

Komponenten

4

Edukt 2

HCID 444972Fumaric AcidHCID 178482470HCID 178482470, Verbindung

Produkt 1

HCID 178482471HCID 178482471, VerbindungAusbeute 68,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a solution of (5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-4-(methylamino)-1,3-thiazol-2(5H)-one (765 mg) in ethanol (15 mL) was added a solution of fumaric acid (197 mg) in ethanol (45 mL). The reaction mixture was stirred at room temperature for 1 hr, the solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate. The obtained powder was recrystallized from ethanol/heptane to give the title compound (662 mg).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. customThe obtained powder was recrystallized from ethanol/heptane

Quellen und Nachweise

ORD-Eintrag
ord-19bd6cf1c467445dbf92355161e552ef
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772277B2

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