4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178496742, Verbindung

HRID 1620713Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1620713
[CH3:1][N:2]([CH3:11])[C:3](=[O:10])[C@H:4]([C@@H:6]([CH3:9])[O:7][CH3:8])[NH2:5].S=[C:13]1[CH2:17][S:16][C:15](=[O:18])[NH:14]1>C(O)C>[CH3:11][N:2]([CH3:1])[C:3](=[O:10])[C@H:4]([C@@H:6]([CH3:9])[O:7][CH3:8])[NH:5][C:13]1[CH2:17][S:16][C:15](=[O:18])[N:14]=1

Komponenten

4

Edukt 2

HCID 15395954-Sulfanylidene-1,3-thiazolidin-2-oneHCID 86678876(2S,3R)-2-amino-3-methoxy-N,N-dimethyl-butanamide

Produkt 1

HCID 178496742HCID 178496742, VerbindungAusbeute 35,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of N,N,O-trimethyl-L-threoninamide (1198 mg) in ethanol (10 mL) was added 4-thioxothiazolidin-2-one (996 mg) at room temperature. The reaction mixture was stirred at room temperature overnight, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (680 mg).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-d7bce9d44053494ab92402ebe4a71ecc
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772277B2

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