4-Sulfanylidene-1,3-thiazolidin-2-one → HCID 178518187, Verbindung
Reaktionsgleichung
[NH2:1][C@H:2]1[C@H:7]([OH:8])[CH2:6][CH2:5][O:4][CH2:3]1.S=[C:10]1[CH2:14][S:13][C:12](=[O:15])[NH:11]1>C(O)C>[O:15]=[C:12]1[N:11]=[C:10]([NH:1][C@H:2]2[C@H:7]([OH:8])[CH2:6][CH2:5][O:4][CH2:3]2)[CH2:14][S:13]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 2-amino-1,5-anhydro-2,4-dideoxy-threo-pentitol (527 mg) in ethanol (100 mL) was added 4-thioxo-1,3-thiazolidin-2-one (590 mg), and the mixture was heated under reflux for 15 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (NH, ethyl acetate) to give the title compound (700 mg).
Aufarbeitung
- temperaturethe mixture was heated
- temperatureunder reflux for 15 hr
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe residue was purified by silica gel column chromatography (NH, ethyl acetate)
Quellen und Nachweise
- ORD-Eintrag
- ord-831048285ab54fbf96293076f12e765d
- Quelldatensatz
- uspto-grants-2014_07
- Patentnummer
- US08772277B2
Notizen zur Reaktion
Wird geladen…