Hydrochloric Acid → 2-hydroxy-N-(5-(methylsulfinyl)thiazol-2-yl)benzamide

HRID 1620892

Reaktionsgleichung

Reaktionsgleichung von HRID 1620892
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:21])[NH:12][C:13]1[S:14][C:15]([S:18]([CH3:20])=[O:19])=[CH:16][N:17]=1)(=O)C.Cl>C1COCC1>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][C:15]([S:18]([CH3:20])=[O:19])=[CH:16][N:17]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 569693972-(5-(Methylsulfinyl)thiazol-2-ylcarbamoyl)phenyl acetate

Produkt 1

HCID 569696152-hydroxy-N-(5-(methylsulfinyl)thiazol-2-yl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 11 (1.0 g, 3.1 mmol) is dissolved in THF (20 mL) and is added under stirring to 2M HCl (100 mL). The reaction is refluxed for one hour and is allowed to cool under stirring over one hour. The product is filtered using a sintered glass funnel, washed with distilled water and THF and dried in high vacuum and affords 12 as a colorless solid.

Aufarbeitung

  1. additionis added
  2. temperatureThe reaction is refluxed for one hour
  3. temperatureto cool
  4. filtrationThe product is filtered
  5. washwashed with distilled water and THF
  6. customdried in high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-7aab2f2e0d7e4a35b9fb58228235f10f
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772502B2

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