2-(1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride → 1-Methyl-5-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethylcarbamoyl)-1H-imidazole-4-carboxylic acid methyl ester
Reaktionsgleichung
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH3:13])[C:9]=1[C:10]([OH:12])=O)=[O:4].Cl.Cl.[CH3:16][N:17]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[C:18]1[CH2:26][CH2:27][NH2:28]>>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][N:8]([CH3:13])[C:9]=1[C:10](=[O:12])[NH:28][CH2:27][CH2:26][C:18]1[N:17]([CH3:16])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=1)=[O:4]Komponenten
3
Versuchsvorschrift
The product was obtained starting from 1-methyl-1H-imidazole-4,5-dicarboxylic acid 4-methyl ester (200 mg, 1.09 mmol) and 2-(1-methyl-1H-benzo[d]imidazol-2-yl)ethanamine dihydrochloride (296 mg, 1.19 mmol) according to the method described in example 8, step 3 as pink foam (156 mg, 457 μmol, 42.1%). MS: M=342.1 (M+H)+