Benzaldehyde → HCID 11807110, Verbindung

HRID 1621158Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1621158
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:9]/[N:10]=[C:11](\[CH3:20])/[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=O>Cl.O1CCOCC1>[CH3:20][C:11]1[N+:10]([O-:9])=[C:1]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[O:8][C:12]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Komponenten

5

Edukt 2

HCID 240BenzaldehydeHCID 95660631-Phenyl-1,2-propanedione-2-oxime

Produkt 1

HCID 11807110HCID 11807110, VerbindungAusbeute 51,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of benzaldehyde (325 mg, 311 μL, 3.06 mmol) in HCl (4M in dioxane, 10 mL was added (E)-2-(hydroxyimino)-1-phenylpropan-1-one (500 mg, 3.06 mmol) at 0-5° C. The ice bath was removed and the mixture was stirred at RT for 24 h. All volatiles were removed and the residue was dissolved in HCl (4M in dioxane, 10 mL). The reaction mixture was stirred at RT for 6 h and concentrated. The obtained suspension was filtered, washed with diethyl ether and dried in vacuo to give the product as colorless solid (398 mg, 1.58 mmol, 51.7%).

Aufarbeitung

  1. customThe ice bath was removed
  2. customAll volatiles were removed
  3. dissolutionthe residue was dissolved in HCl (4M in dioxane, 10 mL)
  4. stirringThe reaction mixture was stirred at RT for 6 h
  5. concentrationconcentrated
  6. filtrationThe obtained suspension was filtered
  7. washwashed with diethyl ether
  8. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-bfeeaac0ee914a47a3590a8951145700
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08772510B2

Notizen zur Reaktion

Wird geladen…