Ethanol → 2-(2-Fluoro-5-((4-(methylsulfonyl)piperazin-1-YL)methyl)pyridin-3-YL)-4-methyl-1,3,5-triazine
Reaktionsgleichung
[F:1][C:2]1[C:7]([C:8]2[N:13]=[C:12]([CH3:14])[N:11]=[C:10](SC)[N:9]=2)=[CH:6][C:5]([CH2:17][N:18]2[CH2:23][CH2:22][N:21]([S:24]([CH3:27])(=[O:26])=[O:25])[CH2:20][CH2:19]2)=[CH:4][N:3]=1.CCO>[Ni]>[F:1][C:2]1[C:7]([C:8]2[N:13]=[C:12]([CH3:14])[N:11]=[CH:10][N:9]=2)=[CH:6][C:5]([CH2:17][N:18]2[CH2:19][CH2:20][N:21]([S:24]([CH3:27])(=[O:26])=[O:25])[CH2:22][CH2:23]2)=[CH:4][N:3]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 70 °C
Versuchsvorschrift
Raney nickel (76 mg, 1.297 mmol) water suspension was added to a mixture of 2-(2-fluoro-5-((4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-3-yl)-4-methyl-6-(methylthio)-1,3,5-triazine (107 mg, 0.259 mmol) in EtOH (5.00 mL, 86 mmol) and the mixture was heated under nitrogen at 70° C. for 1.5 h. The resulting mixture was passed through a short plug of Celite® (diatomaceous earth). The filter cake was washed with MeOH (3×10 mL). The combined organic phases were concentrated to give the crude product, which was used directly in the next step without purification.
Aufarbeitung
- washThe filter cake was washed with MeOH (3×10 mL)
- concentrationThe combined organic phases were concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-bb79c404cb074dcc8614ab2b7e3d5694
- Quelldatensatz
- uspto-grants-2014_07
- Patentnummer
- US08772480B2
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