4-(Trifluoromethyl)benzhydrol → 4-(Trifluoromethyl)benzophenone

HRID 1622568

Reaktionsgleichung

Reaktionsgleichung von HRID 1622568
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:6]([CH:7]([OH:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[C:8]1([C:7]([C:6]2[CH:15]=[CH:16][C:3]([C:2]([F:1])([F:17])[F:18])=[CH:4][CH:5]=2)=[O:14])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

4

Edukt 1

HCID 2588974-(Trifluoromethyl)benzhydrol

Produkt 1

HCID 697674-(Trifluoromethyl)benzophenone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 4-(trifluoromethyl)benzhydrol (1.836 g, 7.3 mmol) in anhydrous DCM (65 mL) was treated with manganese(IV) oxide (<5 micron, activated) (5.7 g, 66 mmol). The resulting suspension was stirred at rt for 12 days. The catalyst was removed by filtration through a Celite® brand filter agent pad. The filtrate was concentrated, and the resulting solid was dried under high vacuum to afford the title compound as a white solid.

Aufarbeitung

  1. customThe catalyst was removed by filtration through a Celite® brand
  2. filtrationfilter agent pad
  3. concentrationThe filtrate was concentrated
  4. customthe resulting solid was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9cb6e0d07be5439e89dbfee072d9e683
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778941B2

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