HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1622646Erstellt: 25. Oktober 2026
Sodium Carbonate → 3-[4-(Cyclohexyloxy)phenyl]pyrazin-2-amine
https://huagongshe.com/reaction/1622646
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 2-Amino-3-chloropyrazine | HCID 276224 | — |
| Edukt | 4-Cyclohexyloxy-benzeneboronic acid | HCID 22289818 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | 1,2-Dimethoxyethane | HCID 8071 | — |
| Produkt | 3-[4-(Cyclohexyloxy)phenyl]pyrazin-2-amine | HCID 66748148 | 77,8% |
Reaktionsschritte
A mixture of sodium carbonate (491 mg), tetrakis(triphenylphosphine)palladium(0) (80 mg), 4-(cyclohexyloxy)phenylboronic acid (612 mg) and 3-chloropyrazin-2-amine (300 mg) in water (3 ml) and DME (15 mL) was stirred at 80° C. for 4 hr. Silica gel was added and the mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give 3-[4-(cyclohexyloxy)phenyl]pyrazin-2-amine (485 mg) as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08778934B2 |
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| Quelldatensatz | uspto-grants-2014_07 |
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| ORD ID | ord-09d525432f4f437eb71091a45beee51a |
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| Quellennotiz | uspto-grants-2014_07 |
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