Sodium Hydroxide → 2-Hydroxymethyl-3-methyl-4-propoxy-pyridine

HRID 1623580Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1623580
C([O:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH3:16])[CH:9]=[CH:8][N:7]=1)(=O)C.[OH-].[Na+]>C1(C)C=CC=CC=1>[OH:4][CH2:5][C:6]1[C:11]([CH3:12])=[C:10]([O:13][CH2:14][CH2:15][CH3:16])[CH:9]=[CH:8][N:7]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 684689472-Acetoxymethyl-3-methyl-4-propoxy-pyridine

Produkt 1

HCID 140971152-Hydroxymethyl-3-methyl-4-propoxy-pyridineAusbeute 48,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

27.8 g of 2-acetoxymethyl-3-methyl-4-propoxy-pyridine was added dropwise into a 25% aqueous solution of sodium hydroxide, and the mixture was allowed to react for one hour at room temperature. Subsequently, the reaction liquid was diluted with toluene, and then the toluene phase was washed with water, dried over anhydrous magnesium sulfate, and then concentrated to dryness, to obtain 11.0 g of 2-hydroxymethyl-3-methyl-4-propoxy-pyridine as an oily matter.

Aufarbeitung

  1. customto react for one hour at room temperature
  2. customSubsequently, the reaction liquid
  3. washthe toluene phase was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-a41668ad33484ba3acc5aa1d60f20f7e
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778975B2

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