Hydrochloric Acid → HCID 67060934, Verbindung

HRID 1623931Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1623931
[CH3:1][C@@H:2]1[CH2:6][CH2:5][C@H:4]([CH3:7])[N:3]1[C:8]([C:10]1([NH:15]C(=O)OC(C)(C)C)[CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:9].[ClH:23]>O1CCOCC1>[ClH:23].[NH2:15][C:10]1([C:8]([N:3]2[C@@H:4]([CH3:7])[CH2:5][CH2:6][C@H:2]2[CH3:1])=[O:9])[CH2:14][CH2:13][CH2:12][CH2:11]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 68182384tert-Butyl 1-((2R,5S)-2,5-Dimethylpyrrolidine-1-carbonyl)cyclopentylcarbamate

Produkt 1

HCID 67060934HCID 67060934, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
23 °C

Versuchsvorschrift

To tert-butyl 1-((2R,5S)-2,5-dimethylpyrrolidine-1-carbonyl)cyclopentylcarbamate (170 mg, 0.548 mmol) was added a 4.0 M dioxane solution of hydrogen chloride (0.137 mL, 0.548 mmol). The mixture was stirred at 23° C. for 64 h then concentrated. The residue was taken up in ether (10 mL). The precipitate was collected by filtration, rinsed with ether, and dried to provide the title compound as a white solid.

Aufarbeitung

  1. concentrationthen concentrated
  2. filtrationThe precipitate was collected by filtration
  3. washrinsed with ether
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ab5df6190f384da08a7ad9b1ad09ea3c
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778950B2

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