Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-A]pyridine-3-carboxylate → Ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate

HRID 1624057Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1624057
C([O:8][C:9]1[C:10]2[N:11]([C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd].[C]>[OH:8][C:9]1[C:10]2[N:11]([C:15]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:16]([CH3:18])[N:17]=2)[CH:12]=[CH:13][CH:14]=1

Komponenten

5

Edukt 2

HCID 44382335Ethyl 8-(benzyloxy)-2-methylimidazo[1,2-A]pyridine-3-carboxylateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 21717316Ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

31.45 g (101.3 mmol) of ethyl 8-(benzyloxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylate were dissolved in 21 of ethyl acetate, 3.15 g of 10% Pd/carbon were added and the mixture was stirred at RT and atmospheric pressure with hydrogen for 5 h. The mixture was filtered through kieselguhr, the filter cake was washed thoroughly with ethyl acetate/methanol and the filtrate was evaporated to dryness. This gave 21.94 g of the target compound (98% of theory, purity 99%).

Aufarbeitung

  1. additionwere added
  2. filtrationThe mixture was filtered through kieselguhr
  3. washthe filter cake was washed thoroughly with ethyl acetate/methanol
  4. customthe filtrate was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-b8d76cec0f004724b3a810f7836fb53c
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08778964B2

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