Ammonia → 2-(Methylthio)pyrimidin-4-amine

HRID 16247

Reaktionsgleichung

Reaktionsgleichung von HRID 16247
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[NH3:10]>CO>[CH3:9][S:8][C:4]1[N:3]=[C:2]([NH2:10])[CH:7]=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 971134-Chloro-2-methylthiopyrimidine

Produkt 1

HCID 2592252-(Methylthio)pyrimidin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 4-chloro-2-methylsulfanylpyrimidine (8 g) and 7N ammonia in methanol (100 mL) at 100° C. was stirred for 2 days in a sealed tube, cooled, concentrated, treated with water, and extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous sodium sulfate, and concentrated. The concentrate was triturated with ethyl ether and filtered. 1H NMR (300 MHz, CDCl3) δ 8.06 (d, 1H), 6.12 (d, 1H), 4.83 (s, 2H), 2.51 (s, 3H).

Aufarbeitung

  1. temperaturecooled
  2. concentrationconcentrated
  3. additiontreated with water
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated
  8. customThe concentrate was triturated with ethyl ether
  9. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-ee4c67b25ee64efdb3c0893c80b0defa
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737159B2

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