Hydrochloric Acid → HCID 178502433, Verbindung

HRID 1625495Notizen

Reaktionsgleichung

C(OC([N:8]1[CH2:12][C@@H:11]([CH3:13])[CH2:10][C@H:9]1[C:14]1[NH:15][CH:16]=[C:17]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]4[CH:56]=[CH:55][C:34]5[NH:35][C:36]([C@@H:38]6[CH2:42][C@H:41]([CH3:43])[CH2:40][N:39]6[C:44](=[O:54])[C@@H:45]([NH:49][C:50]([O:52][CH3:53])=[O:51])[CH:46]([CH3:48])[CH3:47])=[N:37][C:33]=5[CH:32]=4)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[N:18]=1)=O)(C)(C)C.[ClH:57].O1CCOCC1>>[ClH:57].[CH3:53][O:52][C:50](=[O:51])[NH:49][C@H:45]([C:44]([N:39]1[CH2:40][C@@H:41]([CH3:43])[CH2:42][C@H:38]1[C:36]1[NH:35][C:34]2[CH:55]=[CH:56][C:31]([C:28]3[CH:29]=[CH:30][C:25]([C:22]4[CH:23]=[CH:24][C:19]([C:17]5[N:18]=[C:14]([C@@H:9]6[CH2:10][C@H:11]([CH3:13])[CH2:12][NH:8]6)[NH:15][CH:16]=5)=[CH:20][CH:21]=4)=[CH:26][CH:27]=3)=[CH:32][C:33]=2[N:37]=1)=[O:54])[CH:46]([CH3:48])[CH3:47]

Komponenten

Edukt 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 178502432HCID 178502432, Verbindung

Produkt 1

HCID 178502433HCID 178502433, Verbindung

Versuchsvorschrift

(2S,4S)-2-[4-(4′-{2-[(2S,4S)-1-((S)-2-Methoxycarbonylamino-3-methyl-butyryl)-4-methyl-pyrrolidin-2-yl]-1H-benzoimidazol-5-yl}-biphenyl-4-yl)-1H-imidazol-2-yl]-4-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester (75 mg, 0.0987 mmol) is stirred with 4M HCl in dioxane (4 mL, 16 mmol). The reaction mixture is stirred at room temperature for 0.5 hour and concentrated to dryness. The product {(S)-2-methyl-1-[(2S,4S)-4-methyl-2-(5-{4′-[2-((2S,4S)-4-methyl-pyrrolidin-2-yl)-1H-imidazol-4-yl]-biphenyl-4-yl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carbonyl]-propyl}-carbamic acid methyl ester hydrochloride is used as such in the next step.

Aufarbeitung

concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag: ord-1c7678f5ae86406d97cabd82f8b2cd75
Quelldatensatz: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08779156B2

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