Acetonitrile → 2-(5-Bromo-2-chlorophenyl)acetonitrile

Temperatur

0 °C

The above 5-bromo-2-chlorobenzyl chloride was dissolved in acetonitrile (100 ml), and the mixture was cooled to 0° C. Added thereto was tetraethylammonium cyanide (8.8 g), and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure, and the residue was dissolved in ethyl acetate. The solution was washed successively with water, 10% aqueous hydrochloric acid solution, a saturated aqueous sodium hydrogen carbonate solution and brine, and dried over sodium sulfate. The solvent was evaporated under reduced pressure to give 5-bromo-2-chlorophenylacetonitrile as a pale yellow solid, which was used in the subsequent step without further purification.

1. additionAdded
2. customThe solvent was evaporated under reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. washThe solution was washed successively with water, 10% aqueous hydrochloric acid solution
5. dry with materiala saturated aqueous sodium hydrogen carbonate solution and brine, and dried over sodium sulfate
6. customThe solvent was evaporated under reduced pressure

ORD-Eintrag

ord-40ba5598b76b4196a4c57391dda16386

Quelldatensatz

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08785403B2