Hydrochloride methanol → 1260081-87-5

HRID 1626329Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1626329
CO.Cl.[N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[S:14]([NH:17][C:18]2[CH:38]=[CH:37][C:21]([C:22]([N:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)=[O:23])=[CH:20][CH:19]=2)(=[O:16])=[O:15])[CH:7]=[CH:6][CH:5]=1>>[N:24]1([C:22]([C:21]2[CH:20]=[CH:19][C:18]([NH:17][S:14]([C:12]3[CH:11]=[CH:10][CH:9]=[C:8]4[C:13]=3[N:4]=[CH:5][CH:6]=[CH:7]4)(=[O:16])=[O:15])=[CH:38][CH:37]=2)=[O:23])[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 59634969HCID 59634969, Verbindung

Produkt 1

HCID 596349121260081-87-5Ausbeute 94,3 %

Versuchsvorschrift

To a solution of MeOH.HCl, Boc protected amine 138 (2 gm, 4.03 mmol) was added and the resulting mixture was stirred for 1 hr. After completion of reaction, solvent was removed under reduced pressure, washed with water followed by addition of NaHCO3 and extracted with DCM. The organic layer was dried over Na2SO4 and evaporated under reduced pressure to afford product 139 (1.5 gm, 94.30% yield).

Aufarbeitung

  1. additionwas added
  2. customAfter completion of reaction, solvent
  3. customwas removed under reduced pressure
  4. washwashed with water
  5. additionfollowed by addition of NaHCO3
  6. extractionextracted with DCM
  7. dry with materialThe organic layer was dried over Na2SO4
  8. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0363432c785a43418848cd69490da63a
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785450B2

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