Ethyl isocyanate → (S)-2-(4-(3-cyclopropylureido)phenyl)-N-ethyl-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

HRID 1626556Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1626556
[CH:1]1([NH:4][C:5]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[N:15]=[C:16]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]4[CH3:29])[C:17]4[CH2:22][NH:21][CH2:20][C:18]=4[N:19]=3)=[CH:10][CH:9]=2)=[O:6])[CH2:3][CH2:2]1.[CH2:30]([N:32]=[C:33]=[O:34])[CH3:31]>O1CCOCC1>[CH:1]1([NH:4][C:5](=[O:6])[NH:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[N:15]=[C:16]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][C@@H:24]4[CH3:29])[C:17]4[CH2:22][N:21]([C:33]([NH:32][CH2:30][CH3:31])=[O:34])[CH2:20][C:18]=4[N:19]=3)=[CH:12][CH:13]=2)[CH2:2][CH2:3]1

Komponenten

4

Edukt 2

HCID 8022Ethyl isocyanateHCID 46894114(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Produkt 1

HCID 46913766(S)-2-(4-(3-cyclopropylureido)phenyl)-N-ethyl-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of (S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea (example 3) (50 mg 0.13 mmol) in dioxane (3 mL) at room temperature (20° C.) was added ethyl isocyanate (20 uL 0.26 mmol). The reaction mixture was stirred for 16 h. The solvent was removed in vacuo and the solid residue triturated with ether. The solid was collected by filtration and dried in vacuo to afford (32 mg 55%).

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. customthe solid residue triturated with ether
  3. filtrationThe solid was collected by filtration
  4. customdried in vacuo
  5. customto afford (32 mg 55%)

Quellen und Nachweise

ORD-Eintrag
ord-75e7a5b928864ae79b251cb6a4c23537
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785457B2

Notizen zur Reaktion

Wird geladen…