Ethanolamine → HCID 66679185, Verbindung
Reaktionsgleichung
[NH2:1][CH2:2][CH2:3][OH:4].[F:5][C:6]1[CH:7]=[C:8]([C:22]2[N:23]=[C:24]([N:36]3[CH2:41][CH2:40][O:39][CH2:38][C@@H:37]3[CH3:42])[C:25]3[CH2:30][N:29]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:28][C:26]=3[N:27]=2)[CH:9]=[CH:10][C:11]=1[NH:12][C:13](OC1C=CC=CC=1)=[O:14]>>[CH2:34]([O:33][C:31]([N:29]1[CH2:30][C:25]2[C:24]([N:36]3[CH2:41][CH2:40][O:39][CH2:38][C@@H:37]3[CH3:42])=[N:23][C:22]([C:8]3[CH:9]=[CH:10][C:11]([NH:12][C:13]([NH:1][CH2:2][CH2:3][OH:4])=[O:14])=[C:6]([F:5])[CH:7]=3)=[N:27][C:26]=2[CH2:28]1)=[O:32])[CH3:35]Komponenten
3
Versuchsvorschrift
Method as described for example 51, using 2-aminoethanol and (S)-ethyl 2-(3-fluoro-4-((phenoxycarbonyl)amino)phenyl)-4-(3-methylmorpholino)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate as starting materials. The mixture was reduced in vacuo and purified by flash SCX2 chromatography affording the title compound (10 mg, 0.020 mmol, 36%).
Aufarbeitung
- custompurified by flash SCX2 chromatography