Trifluoroacetic acid → 4-(2-chloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)morpholine trifluoroacetate

HRID 1626650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1626650
[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:5]2[CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][C:6]=2[N:7]=1.[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>C(Cl)Cl>[F:27][C:26]([F:29])([F:28])[C:24]([OH:30])=[O:25].[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[C:5]2[CH2:10][NH:9][CH2:8][C:6]=2[N:7]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 71540665Tert-butyl 2-chloro-4-morpholino-5H-pyrrolo[3,4-D]pyrimidine-6(7H)-carboxylate2×

Produkt 1

HCID 866631634-(2-chloro-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yl)morpholine trifluoroacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of tert-butyl 2-chloro-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (intermediate 2) (2.05 g, 6.0 mmol) in TFA (15 ml) and DCM (30 ml) was stirred at room temperature (20° C.) overnight. The material was concentrated in vacuo to give an orange oil, which was used without further purification.

Aufarbeitung

  1. concentrationThe material was concentrated in vacuo
  2. customto give an orange oil, which
  3. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-9d0843c753424da2ba69a74f8a8aa864
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785457B2

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