(R)-tert-butyl 3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylcarbamate → HCID 67224236, Verbindung

HRID 1627134Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1627134
[C:1]([CH2:3][C@@H:4]([NH:13]C(=O)OC(C)(C)C)[C:5]([NH:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:6])#[N:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:13][C@H:4]([CH2:3][C:1]#[N:2])[C:5]([NH:7][CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12]1)=[O:6]

Komponenten

3

Edukt 1

HCID 67225088(R)-tert-butyl 3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylcarbamate

Produkt 1

HCID 67224236HCID 67224236, VerbindungAusbeute 41 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21863450Trifluoroacetic acid methylene chlorideLösungsmittel

Versuchsvorschrift

A mixture of (R)-tert-butyl 3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylcarbamate and 50% TFA/DCM (10 mL) was stirred for 1 h. Following reaction, the mixture was concentrated to afford the title compound as a clear oil (TFA salt, 0.265 g, 41%). The product was pure by TLC (visualized by ninhydrin stain).

Aufarbeitung

  1. customreaction
  2. concentrationthe mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ed19c90c470c41d486ea7dc9dfcbd887
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785429B2

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