Hydrochloric Acid → HCID 58382001, Verbindung

HRID 1627993Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1627993
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([Si:13]([CH:20]([CH3:22])[CH3:21])([CH:17]([CH3:19])[CH3:18])[CH:14]([CH3:16])[CH3:15])[CH:9]=[C:10]([CH2:11][CH3:12])[C:3]=12.[Li]C(CC)C.CN([CH:31]=[O:32])C.Cl.C([O-])(O)=O.[Na+]>C1COCC1.CCOC(C)=O>[Cl:1][C:2]1[C:7]([CH:31]=[O:32])=[CH:6][N:5]=[C:4]2[N:8]([Si:13]([CH:14]([CH3:15])[CH3:16])([CH:20]([CH3:21])[CH3:22])[CH:17]([CH3:19])[CH3:18])[CH:9]=[C:10]([CH2:11][CH3:12])[C:3]=12

Komponenten

8

Edukt 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 516892Sodium BicarbonateHCID 58382052HCID 58382052, VerbindungHCID 178418400CID 53628100

Produkt 1

HCID 58382001HCID 58382001, VerbindungAusbeute 91,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
-70 °C

Versuchsvorschrift

4-Chloro-3-ethyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (1.5 g, 4.45 mmol) in THF (25 mL) was cooled to about −70° C. then the sec-BuLi (1.4 M in cyclohexane, 6.36 mL, 8.90 mmol) was added over about 10 min. The mixture was stirred for about 1.25 h at about −70° C. then DMF (1.00 mL, 13.4 mmol) was added over about 5 min. The mixture was stirred for about 30 min then HCl (4.0 M in 1,4-dioxane, 1.11 mL, 4.45 mmol) was added. The mixture was allowed to warm to rt then saturated aqueous NaHCO3 (50 mL) and EtOAc (50 mL) were added. The layers were separated then the aqueous layer was extracted with EtOAc (25 mL) then the combined organics were extracted with saturated aqueous NaCl (25 mL), dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The material was purified on a 80 g silica gel column with 9:1 heptane/EtOAc as an eluent to give 4-chloro-3-ethyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde (1.48 g, 91%): LC/MS (Table 2, Method g) Rt=2.44 min; MS m/z 365 (M+H)+.

Aufarbeitung

  1. stirringThe mixture was stirred for about 30 min
  2. temperatureto warm to rt
  3. customThe layers were separated
  4. extractionthe aqueous layer was extracted with EtOAc (25 mL)
  5. extractionthe combined organics were extracted with saturated aqueous NaCl (25 mL)
  6. dry with materialdried over anhydrous MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure
  9. customThe material was purified on a 80 g silica gel column with 9:1 heptane/EtOAc as an eluent

Quellen und Nachweise

ORD-Eintrag
ord-247498361eec4ab68ab7541c9d9ddcef
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785639B2

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