Cesium carbonate → 2-(4-Carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester

HRID 1628171

Reaktionsgleichung

Reaktionsgleichung von HRID 1628171
[Cl:1][C:2]([Cl:26])([Cl:25])[CH2:3][O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][S:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16](CC(O)=O)[CH:15]=1.SC1C=CC([CH2:34][C:35]([OH:37])=[O:36])=CC=1.ClC(Cl)(Cl)COC(=O)C1C=CC=CC=1CBr.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C>[Cl:26][C:2]([Cl:1])([Cl:25])[CH2:3][O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][S:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:34][C:35]([OH:37])=[O:36])=[CH:18][CH:19]=1

Komponenten

6

Edukt 4

HCID 10796Cesium carbonateHCID 33905114-Mercaptophenylacetic acidHCID 668648212-(3-Carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl esterHCID 668652492-Bromomethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Produkt 1

HCID 668648682-(4-Carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

The titled compound was prepared according to the method described for 2-(3-carboxymethyl-phenylsulfanylmethyl)-benzoic acid 2,2,2-trichloro-ethyl ester above from 4-mercapto-phenylacetic acid (0.73 g, 4.33 mmol), 2-bromomethyl-benzoic acid 2,2,2-trichloro-ethyl ester (1.50 g, 4.33 mmol), cesium carbonate (1.69 g, 5.20 mmol) and DMF (25 mL). The crude material (1.88 g, 100%) was used for the next step without further purification; Mass spectrum: M−H+ 432.

Aufarbeitung

  1. customThe crude material (1.88 g, 100%) was used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-f1269ca7c99b42a38fed9f48d2cee929
Quelldatensatz
uspto-grants-2014_07
Patentnummer
US08785681B2

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