Methylhydrazine → HCID 86664828, Verbindung

Reaktionsgleichung

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[NH:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.[CH3:14]NN>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1

Komponenten

Edukt 2

HCID 6061Methylhydrazine

HCID 178507310HCID 178507310, Verbindung3×

Produkt 1

HCID 86664828HCID 86664828, VerbindungAusbeute 89 %

Versuchsvorschrift

This title intermediate was prepared starting from 18.B (3.10 g, 17.3 mmol) according the procedure described above for conversion of 18.B to 18.C, except that methylhydrazine (3.5 equiv.) was used. The crude product was purified by flash chromatography on silica gel using 0-8% MeOH/CH2Cl2 for elution to provide 23.A (3.44 g mg, 89%) as a brown solid.

Aufarbeitung

customThe crude product was purified by flash chromatography on silica gel using 0-8% MeOH/CH2Cl2 for elution

Quellen und Nachweise

ORD-Eintrag: ord-18456180be1243f0a8af25b68f19576c
Quelldatensatz: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08785468B2

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