HCID 86664828, Verbindung → HCID 67497326, Verbindung

Reaktionsgleichung

Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:15][C:16]1NN=C(C2C=CN=C(NC)C=2)C=1>>[NH2:13][C:11]1[N:10]([CH3:14])[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:15][CH3:16])[CH:7]=2)[CH:12]=1

Komponenten

Edukt 2

HCID 86664828HCID 86664828, Verbindung

HCID 178482070HCID 178482070, Verbindung

Produkt 1

HCID 67497326HCID 67497326, VerbindungAusbeute 79 %

Versuchsvorschrift

This title intermediate was prepared starting from 23.A (2.10 g, 10.0 mmol) according the procedure described above for conversion of 18.0 to 18.D. The crude product was purified by flash chromatography using 0-10% MeOH/CH2Cl2 for elution to provide 23.B as white solid (1.61 g, 79%).

Aufarbeitung

customThe crude product was purified by flash chromatography
washfor elution

Quellen und Nachweise

ORD-Eintrag: ord-71db85fd8d334e30b56879e7f0db2253
Quelldatensatz: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08785468B2

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