Hydrochloric Acid → 1-(Trifluoromethyl)cyclopropanamine hydrochloride
Reaktionsgleichung
[F:1][C:2]([F:15])([F:14])[C:3]1([NH:6]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1.[ClH:16]>>[ClH:16].[F:1][C:2]([F:15])([F:14])[C:3]1([NH2:6])[CH2:5][CH2:4]1Komponenten
3
Versuchsvorschrift
A solution of tert-butyl 1-(trifluoromethyl)cyclopropylcarbamate (0.3 g, 1.3 mmol) in HCl (4 N dioxane, 6.7 mL, 27 mmol) was stirred at ambient temperature overnight. The reaction was then concentrated to yield the crude product as white solid, which was used directly in the next step assuming quantitative yield.
Aufarbeitung
- concentrationThe reaction was then concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-4b2961abd96b4c80aa3a7da09cbbd5fc
- Quelldatensatz
- uspto-grants-2014_07
- Patentnummer
- US08791123B2
Notizen zur Reaktion
Wird geladen…