Methanol → Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

HRID 1632118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1632118
[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4](Cl)=[O:5].C(N(CC)CC)C.[CH3:16][OH:17]>>[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([O:17][CH3:16])=[O:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 8471TriethylamineHCID 613453-Chloro-2,2-dimethylpropanoyl chloride

Produkt 1

HCID 543185Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

Versuchsvorschrift

219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was mixed with water and extracted with ether. The extract was dried (MgSO4), and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (3A), b.p.: 40°-50° C. (14 Torr.).

Aufarbeitung

  1. temperaturea chilled (0°-5° C.)
  2. custommost of the methanol was evaporated under reduced pressure
  3. additionThe residue was mixed with water
  4. extractionextracted with ether
  5. dry with materialThe extract was dried (MgSO4)
  6. customthe solvent was evaporated
  7. distillationThe residue was distilled

Quellen und Nachweise

ORD-Eintrag
ord-c7a50dcc66724a2796590abdda9c6f3b
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04474598

Notizen zur Reaktion

Wird geladen…