Sodium Hydroxide → 1-Butanone, 1-(4-aminophenyl)-

HRID 1632510

Reaktionsgleichung

Reaktionsgleichung von HRID 1632510
[NH:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:15])[CH2:12][CH2:13][CH3:14])=[CH:7][CH:6]=1)C(C)=O.[OH-].[Na+]>Cl>[NH2:1][C:5]1[CH:6]=[CH:7][C:8]([C:11](=[O:15])[CH2:12][CH2:13][CH3:14])=[CH:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 4304236N-(4-Butyrylphenyl)acetamide

Produkt 1

HCID 155271-Butanone, 1-(4-aminophenyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

20 g of p-acetaminobutyrophenone are suspended in 40 ml of semi-concentrated hydrochloric acid and the suspension is heated under reflux for 25 minutes and poured into a mixture of 100 ml of ice and 30 ml of concentrated sodium hydroxide solution. The mixture is filtered with suction, then the residue is washed twice with ice-cold water, dried in the atmosphere and recrystallised from methanol/water (20 ml+100 ml). p-Aminobutyrophenone having a melting point of 93°-94° is obtained.

Aufarbeitung

  1. temperaturethe suspension is heated
  2. temperatureunder reflux for 25 minutes
  3. filtrationThe mixture is filtered with suction
  4. washthe residue is washed twice with ice-cold water
  5. customdried in the atmosphere
  6. customrecrystallised from methanol/water (20 ml+100 ml)

Quellen und Nachweise

ORD-Eintrag
ord-c84a30cb5b8e46ada567659ae69b8810
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04476132

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