HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium borohydride → 4-Hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium borohydride | HCID 4311764 | — |
| Edukt | Methyl 2-(3-methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylate | HCID 13362002 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 4-Hydroxymethyl-5-(3-methoxyphenyl)-1-phenylpyrrolidin-2-one | HCID 13362003 | — |
Reaktionsschritte
To 26.7 gm. of methyl 2-(3-methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylate in 200 ml of absolute methanol was added slowly at 0°-10° 24.8 gm. of sodium borohydride. The reaction was run and worked up following the procedure of example 1D. Drying (Na2SO4), filtration, and concentration in vacuo provided 17.2 gm. of colorless crystals, m.p. 123°-126°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04476311 |
| Quelldatensatz | uspto-grants-1984_10 |
| ORD ID | ord-991b093775c24b6d99dbac4e8ef4c997 |
| Quellennotiz | uspto-grants-1984_10 |