Triethylamine → HCID 13390107, Verbindung

HRID 1632739

Reaktionsgleichung

Reaktionsgleichung von HRID 1632739
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[S:15][C:14]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl.[CH3:28][C:29]([CH3:37])([CH2:33][N:34]([CH3:36])[CH3:35])[C:30](Cl)=[O:31]>CC(C)=O>[CH3:28][C:29]([CH3:37])([CH2:33][N:34]([CH3:36])[CH3:35])[C:30]([O:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[S:15][C:14]([S:16](=[O:17])(=[O:18])[NH2:19])=[CH:13][CH:12]=2)(=[O:9])=[O:10])=[CH:4][CH:3]=1)=[O:31]

Komponenten

5

Edukt 3

HCID 8471Triethylamine2×HCID 127368925-(4-Hydroxyphenyl)sulfonylthiophene-2-sulfonamideHCID 204423693-(Dimethylamino)-2,2-dimethylpropanoyl chloride--hydrogen chloride (1/1)

Produkt 1

HCID 13390107HCID 13390107, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A solution of 5-[(4-hydroxyphenyl)sulfonyl]thiophene-2-sulfonamide (3.19 g. 0.01 mole) in acetone (60 ml) at -10° was treated with triethylamine (1.11 g, 0.011 mole). Then 2,2-dimethyl-3-dimethylaminopropionyl chloride hydrochloride (2.20 g, 0.011 mole) was added portionwise, during 15 minutes at -10°. The cooling bath was removed and stirring was continued. After 72 hours at room temperature, the reaction mixture was heated on a steam bath for 4 hours. The reaction mixture was cooled and treated with triethylamine (1.11 g, 0.011 mole) and heated on a steam bath for 1 hour.

Aufarbeitung

  1. customThe cooling bath was removed
  2. temperaturethe reaction mixture was heated on a steam bath for 4 hours
  3. temperatureThe reaction mixture was cooled
  4. temperatureheated on a steam bath for 1 hour

Quellen und Nachweise

ORD-Eintrag
ord-ff27abafca544d05a8bf1bca3098d36a
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04477466

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