HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydroxylamine → 6-[1-Hydroxy-2-(N-tert-butylbenzylamino)ethyl]-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydroxylamine | HCID 787 | — |
| Edukt | N-(1,1-Dimethylethyl)benzenemethanamine | HCID 76908 | — |
| Edukt | 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine | HCID 13748403 | — |
| Edukt | 6-[1-hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine | HCID 53930912 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 6-[1-Hydroxy-2-(N-tert-butylbenzylamino)ethyl]-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine | HCID 13340177 | — |
Reaktionsschritte
A solution of 33.0 g. (0.13 mole) 6-(1,2-epoxyethyl)-2-phenyl-4H-1,3-dioxino[5,4-b]pyridine and 22.0 g. (0.135 mole) of N-tert-butylbenzylamine in 200 ml. of methanol was heated to the reflux temperature overnight. Upon cooling there deposited 6-[1-hydroxy-2-(N-tert-butylbenzylamino)ethyl]pyridine which was recrystallized from isopropanol to give 29.4 g. (54%) of the amino alcohol m.p. 126°-130° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04477671 |
| Quelldatensatz | uspto-grants-1984_10 |
| ORD ID | ord-9c1515a111ee4f589a1a79d016b912d1 |
| Quellennotiz | uspto-grants-1984_10 |