Lumazine → 3-Amino-5,6-dichloropyrazine-2-carbaldehyde

HRID 1633237

Reaktionsgleichung

Reaktionsgleichung von HRID 1633237
[NH2:1][C:2]1[C:7]([C:8](OC)=[O:9])=[N:6][C:5]([Cl:12])=[C:4]([Cl:13])[N:3]=1.NC1C(C(OC)=O)=NC=CN=1.C1N=C2C(NC(NC2=NC=1)=O)=O>>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:12])=[C:4]([Cl:13])[N:3]=1

Komponenten

4

Edukt 3

HCID 10250LumazineHCID 72669Methyl 3-aminopyrazinecarboxylateHCID 73828Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate2×

Produkt 1

HCID 133678713-Amino-5,6-dichloropyrazine-2-carbaldehyde

Versuchsvorschrift

The 2-amino-5,6-dichloro-3-(methoxycarbonyl)pyrazine (also named methyl 3-amino-5,6-dichloropyrazinecarboxylate) may be prepared by a method described in J. Med. Chem. 10, 66 (1967), from 2-amino-3-carbomethoxypyrazine, reported in J. Am. Chem. Soc. 67, 1711 (1945), which in turn is prepared from lumazine whose preparation from readily available materials is reported in J. Am. Chem. Soc. 67, 802 (1945).

Quellen und Nachweise

ORD-Eintrag
ord-177d836925c84387a85e5eded9c21c13
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04479953

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