3-Hydrazinopyridine → HCID 178479606, Verbindung

HRID 1633250

Reaktionsgleichung

Reaktionsgleichung von HRID 1633250
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[N:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:12]([O:14]CC)=O.[NH:17]([C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[NH2:18]>CO>[ClH:1].[N:21]1[CH:22]=[CH:23][CH:24]=[C:19]([N:17]2[C:12](=[O:14])[C:3]3=[CH:4][NH:5][C:6]4[CH:7]=[CH:8][N:9]=[CH:10][C:11]=4[C:2]3=[N:18]2)[CH:20]=1

Komponenten

4

Edukt 2

HCID 109095193-HydrazinopyridineHCID 17608818Ethyl 4-chloro-1,6-naphthyridine-3-carboxylate

Produkt 1

HCID 178479606HCID 178479606, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2.84 g of ethyl 4-chloro-1,6-naphthyridine-3-carboxylate and 1.35 g of 3-hydrazinopyridine in 36 ml of methanol is stirred at room temperature for 2.5 hours, then refluxed for 4.5 hours, then cooled in an ice bath and filtered. Collected solid is washed with methanol, then with ether to yield 2-(3-pyridyl)pyrazolo[4,3-c][1,6]naphthyridin-3-(5H)-one hydrochloride, m.p. 302°-305°.

Aufarbeitung

  1. temperaturerefluxed for 4.5 hours
  2. temperaturecooled in an ice bath
  3. filtrationfiltered
  4. customCollected solid
  5. washis washed with methanol

Quellen und Nachweise

ORD-Eintrag
ord-927d03d9546a4246865ca23991daf5ec
Quelldatensatz
uspto-grants-1984_10
Patentnummer
US04479955

Verknüpfte Notizen

Wird geladen…