HCID 53671061, Verbindung → HCID 70464836, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C@@H:14]([NH2:22])[C@H:12]1[OH:13].[C:23]([O:27][C:28]([NH:30][C@H:31]([C:51](O)=[O:52])[CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42][NH:43][C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])=[CH:35][CH:34]=1)=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C@@H:14]([NH:22][C:51](=[O:52])[C@H:31]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([O:39][CH2:40][CH2:41][CH2:42][NH:43][C:44]([O:46][C:47]([CH3:50])([CH3:49])[CH3:48])=[O:45])=[CH:37][CH:38]=2)[NH:30][C:28]([O:27][C:23]([CH3:26])([CH3:24])[CH3:25])=[O:29])[C@H:12]1[OH:13]Komponenten
3
Versuchsvorschrift
Ethyl 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-[N-tert-butoxycarbonyl-O-(3-tert-butoxycarbonylaminopropyl)-L-tyrosylamino]-β-D-ribofuranuronate (770 mg) was prepared by reacting ethyl 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-amino-β-D-ribofuranuronate (462 mg) prepared in Example 63 with N-tert-butoxycarbonyl-O-(3-tert-butoxycarbonylaminopropyl)-L-tyrosine (906 mg) prepared in Preparation 7 (4) according to a similar manner to that of Example 64, mp. 125°-131° C. (dec.).
Quellen und Nachweise
- ORD-Eintrag
- ord-c65af1261c8547a49fb6efa16afdc5de