Sodium Hydroxide → 4-(5-Fluoro-2-methoxyphenyl)piperidine

HRID 1633576Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1633576
C([N:3]1[CH2:8][CH2:7][CH:6]([C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[O:16][CH3:17])[CH2:5][CH2:4]1)=O.[OH-].[Na+]>Cl.CO>[F:15][C:13]1[CH:12]=[CH:11][C:10]([O:16][CH3:17])=[C:9]([CH:6]2[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]2)[CH:14]=1

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 15512821HCID 15512821, Verbindung

Produkt 1

HCID 155128224-(5-Fluoro-2-methoxyphenyl)piperidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

The crude product of 1-formyl-4-(5-fluoro-2-methoxy-phenyl)-piperidine (0.80 g, 3.4 mmole) was dissolved in HCl (16 mL, 0.5 N) and MeOH (5 mL), and the mixture was brought to reflux for 16 hours. The mixture was cooled to room temperature and basified with NaOH (2.5 N), and extracted with EtOAc (3×25 mL) to give 4-(5-fluoro-2-methoxy-phenyl)-piperidine which was used directly without further purification.

Aufarbeitung

  1. temperatureto reflux for 16 hours
  2. extractionextracted with EtOAc (3×25 mL)

Quellen und Nachweise

ORD-Eintrag
ord-179f056309ed4aac9714856b40099491
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06503928B2

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