Potassium Carbonate → HCID 18679523, Verbindung

HRID 1633664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1633664
C[Si]([C:5]#[C:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:21]3[C:16](=[CH:17][C:18]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)=[CH:9][CH:8]=1)(C)C.C([O-])([O-])=O.[K+].[K+]>CO>[C:6]([C:7]1[CH:12]=[CH:11][C:10]([N:13]2[C:21]3[C:16](=[CH:17][C:18]([C:22]#[C:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:19][CH:20]=3)[CH:15]=[CH:14]2)=[CH:9][CH:8]=1)#[CH:5]

Komponenten

4

Edukt 2

HCID 11430Potassium CarbonateHCID 186794765-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol

Produkt 1

HCID 18679523HCID 18679523, VerbindungAusbeute 87,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

970 mg (2.6 mmol) 5-[1-(4-Trimethylsilanylethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol in 10 ml MeOH were treated with 41.4 mg (3 mmol) K2CO3. The solution was concentrated, the residue dissolved in ether and 0.5M HCl and the organic phase was washed with water and dried over Na2SO4. Column chromatography on silica gel with ether yielded 680 mg (87%) 5-[1-(4-Ethynyl-phenyl)-1H-indol-5-yl]-pent-4-yn-1-ol as orange oil, MS: 299 (M).

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. dissolutionthe residue dissolved in ether
  3. wash0.5M HCl and the organic phase was washed with water
  4. dry with materialdried over Na2SO4

Quellen und Nachweise

ORD-Eintrag
ord-d865e9172b944a3db7eca46594e8f725
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06503907B2

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