Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylate → (2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidine

HRID 1634337Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1634337
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH:3]1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[CH3:21][O:22][C:23]1[CH:30]=[CH:29][C:28]([C:31]([F:37])([F:36])[C:32]([F:35])([F:34])[F:33])=[CH:27][C:24]=1[CH:25]=O.C(OC(N1CCC[C@H](NCC2C=C(C(F)(F)C)C=CC=2OC(F)(F)F)[C@@H]1C1C=CC=CC=1)=O)(C)(C)C>>[C:11]([O:10][C:8]([N:4]1[CH2:5][CH2:6][CH2:7][C@H:2]([NH:1][CH2:25][C:24]2[CH:27]=[C:28]([C:31]([F:36])([F:37])[C:32]([F:33])([F:34])[F:35])[CH:29]=[CH:30][C:23]=2[O:22][CH3:21])[C@@H:3]1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Komponenten

4

Edukt 3

HCID 10214733Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylateHCID 186776122-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzaldehydeHCID 70001814(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1,1-difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine

Produkt 1

HCID 86757655(2S,3S)-1-tert-Butoxycarbonyl-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino2-phenylpiperidine

Versuchsvorschrift

This Compound was prepared from Compound 12 and Compound 40 in the same manner of Compound 26. This was employed in the next step without further purification.

Aufarbeitung

  1. customThis was employed in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-52a65bf15e6d490e9911b3627ff58b04
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06506775B1

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