Sodium Hydroxide → 2,5-Dimethyl-3-furoic acid

HRID 1634620

Reaktionsgleichung

Reaktionsgleichung von HRID 1634620
[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C>[CH3:1][C:2]1[O:3][C:4]([CH3:12])=[CH:5][C:6]=1[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 1414573-Furancarboxylic acid, 2,5-dimethyl-, ethyl ester

Produkt 1

HCID 694652,5-Dimethyl-3-furoic acidAusbeute 85,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 3.2 g of ethyl 2,5-dimethylfuran-3-carboxylate, 35 ml of ethanol and 20 ml of 2 N sodium hydroxide was stirred at room temperature for 1.5 hours followed by heating under reflux for an hour. After the reaction mixture was allowed to cool to room temperature, it was concentrated under reduced pressure. The residue was dissolved in water and acidified with diluted sulfuric acid. Precipitated crystals were collected by filtration, washed with water and dried to give 2.27 g of 2,5-dimethylfuran-3-carboxylic acid in a 85% yield.

Aufarbeitung

  1. temperatureby heating
  2. temperatureunder reflux for an hour
  3. temperatureto cool to room temperature
  4. concentrationit was concentrated under reduced pressure
  5. dissolutionThe residue was dissolved in water
  6. customPrecipitated crystals
  7. filtrationwere collected by filtration
  8. washwashed with water
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-facb7271855e4342aee45a9b49ed1170
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06506913B2

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