Potassium Carbonate → [1-({4-[amino(hydroxyimino)methyl]phenyl}sulfonyl)-4-piperidinyl]methyl-carbamic Acid t-butyl Ester

HRID 1634830Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1634830
[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:11][CH2:10]1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].Cl.[OH-:34].[NH4+:35]>C(O)C>[C:1]([O:5][C:6](=[O:26])[NH:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([S:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([NH2:35])=[N:25][OH:34])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:13][CH2:14]1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 13908798HCID 13908798, VerbindungHCID 70117214{1-[(4-Cyanophenyl)sulfonyl]-4-piperidinyl}methylcarbamic acid t-butyl ester

Produkt 1

HCID 74062249[1-({4-[amino(hydroxyimino)methyl]phenyl}sulfonyl)-4-piperidinyl]methyl-carbamic Acid t-butyl Ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

{1-[(4-cyanophenyl)sulfonyl]-4-piperidinyl}methylcarbamic acid t-butyl ester (1 g, 2.6 mmol), potassium carbonate (1.8 g, 13 mmol), and ammonium hydroxide hydrochloride (0.916 g, 13 mmol) were heated in ethanol (5 ml) at reflux for 2.5 days. The reaction was cooled in an ice-water bath, and filtered. The solid was washed with cold ethanol, and evaporated to a white solid (0.870 g, 2.10 mmol).

Aufarbeitung

  1. temperatureat reflux for 2.5 days
  2. temperatureThe reaction was cooled in an ice-water bath
  3. filtrationfiltered
  4. washThe solid was washed with cold ethanol

Quellen und Nachweise

ORD-Eintrag
ord-fcb8a318b3014d3ab5a710d5f541a8fd
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06506901B2

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