Methanol → (4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one

HRID 16350Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 16350
CO.[F:3][C:4]1[CH:5]=[C:6]([C@@H:12]2[CH2:17][O:16][CH2:15][C@@H:14]3[CH:18]=[CH:19][CH2:20][C:21](=[O:22])[N:13]23)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]>[H][H].[Pt]=O>[F:3][C:4]1[CH:5]=[C:6]([C@@H:12]2[CH2:17][O:16][CH2:15][C@@H:14]3[CH2:18][CH2:19][CH2:20][C:21](=[O:22])[N:13]23)[CH:7]=[C:8]([F:11])[C:9]=1[F:10]

Komponenten

5

Edukt 2

HCID 887MethanolHCID 67464206(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one

Produkt 1

HCID 44124045(4R,9aS)-4-(3,4,5-Trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-oneAusbeute 100,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

Platinum oxide (20.1 mg) was added to a methanol solution (6 mL) of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg). The resulting reaction solution was stirred at room temperature for 2 hr in hydrogen atmosphere and then filtered through Celite. The filtrate was concentrated under reduced pressure to give 252 mg of the title compound. The physical property values of this compound were as follows:

Aufarbeitung

  1. customThe resulting reaction solution
  2. filtrationfiltered through Celite
  3. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-35f06373a37f4b7c9cbccb1f649396bd
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07737141B2

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