Thionyl Chloride → HCID 12011185, Verbindung

HRID 1635575Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1635575
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16]O>>[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16][Cl:3]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 12011184HCID 12011184, Verbindung

Produkt 1

HCID 12011185HCID 12011185, Verbindung

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1-(2′-chlorobenzyl)-4,5-dimethyl-2-hydroxymethyl-imidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl chloride is evaporated in vacuo. The residue is dissolved in 10 ml of dichloromethane, then evaporated in vacuo. This is repeated twice to give 1-(2′-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole as a cream colored foam which is used in next step without further purification.

Aufarbeitung

  1. customthe thionyl chloride is evaporated in vacuo
  2. dissolutionThe residue is dissolved in 10 ml of dichloromethane
  3. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6e8114d43c824ef5bd49c1e52ae14c53
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06509366B2

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