Nitric Acid → 2-Chloro-6-fluoro-3-nitrobenzeneacetic acid

HRID 1635923

Reaktionsgleichung

Reaktionsgleichung von HRID 1635923
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]([OH:12])=[O:11].S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>>[Cl:1][C:2]1[C:7]([N+:18]([O-:20])=[O:19])=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[CH2:9][C:10]([OH:12])=[O:11]

Komponenten

4

Edukt 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 1234642-Chloro-6-fluorophenylacetic acid

Produkt 1

HCID 696933382-Chloro-6-fluoro-3-nitrobenzeneacetic acidAusbeute 78 %

Versuchsvorschrift

1.89 g of 2-chloro-6-fluoro-phenylacetic acid was suspended in 20 ml of concentrated nitric acid. After the addition of 10 ml of concentrated sulfuric acid, the resulting mixture was heated under reflux for 3.5 hours. After the reaction mixture was poured into ice water, the resulting precipitate was collected by filtration, washed with a small amount of purified water, and then dried. Thus, 1.83 g (78% yield) of the title compound was obtained as a white powder.

Aufarbeitung

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 3.5 hours
  3. filtrationthe resulting precipitate was collected by filtration
  4. washwashed with a small amount of purified water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-62993e7f5fc24a7da8ff2c1508456f84
Quelldatensatz
uspto-grants-2003_01
Patentnummer
US06511997B1

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