HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Iodine chloride → 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Iodine chloride | HCID 24640 | — |
| Edukt | 4-(6-Methoxy-1,3-benzothiazol-2-yl)aniline | HCID 391870 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Produkt | 2-(4'-Amino-3'-iodophenyl)-6-methoxybenzothiazole | HCID 10068437 | 56,1% |
Reaktionsschritte
2-(4'-Aminophenyl)-6-methoxybenzothiazole (0.22 g, 0.84 mmol) was treated with iodine monochloride (0.21 g, 1.3 mmol) in acetic acid according to the above-described general procedure for iodination. Crude product was purified by flash chromatography on silica gel, using ethyl acetate-hexane (1:3) as eluent, to give brown small crystals (0.18 g, 54.9%), m.p. 179.2-181.1° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06034246 |
| Quelldatensatz | uspto-grants-2000_03 |
| ORD ID | ord-06fc31bab1024d1a891d176b03be7e52 |
| Quellennotiz | uspto-grants-2000_03 |