6-Chlorothieno[2,3-b]pyridine-2-sulfonyl chloride → HCID 54285997, Verbindung

HRID 1636781

Reaktionsgleichung

Reaktionsgleichung von HRID 1636781
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].[Cl:18][C:19]1[N:24]=[C:23]2[S:25][C:26]([S:28](Cl)(=[O:30])=[O:29])=[CH:27][C:22]2=[CH:21][CH:20]=1>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:28]([C:26]2[S:25][C:23]3=[N:24][C:19]([Cl:18])=[CH:20][CH:21]=[C:22]3[CH:27]=2)(=[O:29])=[O:30])[C:4]1=[O:17])#[N:13]

Komponenten

3

Edukt 2

HCID 181763556-Chlorothieno[2,3-b]pyridine-2-sulfonyl chlorideHCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

Produkt 1

HCID 54285997HCID 54285997, Verbindung

Versuchsvorschrift

The title compound is prepared from 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 1, Part E using 6-chlorothieno[2,3-b]pyridine-2-sulfonyl chloride in place of benzo[b]thiophene-2-sulfonyl chloride. The crude product is purified by column chromatography eluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2 to afford a white solid.

Aufarbeitung

  1. customThe crude product is purified by column chromatography
  2. washeluting with a gradient of 10% EtOAc/CH2Cl2 to 25% EtOAc/CH2Cl2
  3. customto afford a white solid

Quellen und Nachweise

ORD-Eintrag
ord-47226c2d084a4245bbb9b3b309ba2d06
Quelldatensatz
uspto-grants-2000_03
Patentnummer
US06034093

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