Hydrochloric Acid → 5-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochloride

HRID 1637282Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1637282
[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1.[ClH:20]>C(O)C>[ClH:20].[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 101988185-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole

Produkt 1

HCID 193483565-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochlorideAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A portion (1.0 g) of the compound obtained in Example 81 was suspended in ethanol (10 ml) and to the suspension was added a solution (2.5 ml) of 20% hydrochloric acid in ethanol. The mixture was stirred for 10 minutes at room temperature. The reaction mixture was concentrated under reduced pressure. The crystals obtained were washed with ether and ether/methanol to yield 0.87 g (76%) of the titled compound as pale brown crystals.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe crystals obtained
  3. washwere washed with ether and ether/methanol

Quellen und Nachweise

ORD-Eintrag
ord-d6fba87e077448f9ad96bfde303fbda8
Quelldatensatz
uspto-grants-2000_03
Patentnummer
US06040331

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