Trifluoroacetic acid → 4-Amino-6-chloropyrimidine-2-thiol
Reaktionsgleichung
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9]CC2C=CC(OC)=CC=2)[N:3]=1.FC(F)(F)C(O)=O>>[CH:7]1[C:2]([NH2:1])=[N:3][C:4](=[S:9])[NH:5][C:6]=1[Cl:8]Komponenten
3
Versuchsvorschrift
4-amino-6-chloro-2-(4-methoxyphenylmethylthio)-pyrimidine (11.0 g, 39.15 mmol; Cpd #93) and trifluoroacetic acid (84 ml) are heated to reflux for 20 hours, then the excess solvent is removed in vacuo. The sample is triturated with chloroform then stirred with ether and filtered. The solid is washed with ether then air dried, mp >320° C.
Aufarbeitung
- temperatureto reflux for 20 hours
- customthe excess solvent is removed in vacuo
- customThe sample is triturated with chloroform
- filtrationfiltered
- washThe solid is washed with ether
- customair dried
Quellen und Nachweise
- ORD-Eintrag
- ord-216679d7b3aa436191bed64e336747e4
- Quelldatensatz
- uspto-grants-2000_03
- Patentnummer
- US06043248
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