Selenium Dioxide → 4-(tert-butyl)picolinaldehyde

HRID 1637730Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1637730
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][OH:12])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[Se](=O)=O>O1CCOCC1.ClCCl>[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH:11]=[O:12])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Komponenten

5

Edukt 2

HCID 24007Selenium DioxideHCID 18799645(4-(tert-Butyl)pyridin-2-yl)methanol

Produkt 1

HCID 187996954-(tert-butyl)picolinaldehydeAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
82.5 °C

Versuchsvorschrift

4-t-Butyl-2-hydroxymethyl-pyridine (4.13 g, 25 mmole) is dissolved in 75 ml dioxane in a 200 ml one neck round bottom flask under nitrogen. The solution is treated with selenium dioxide (1.53 g, 13.75 mmole) and the reaction is warmed to 80-85° C. for 1 h. The mixture is cooled, diluted with dichloromethane, and is filtered through celite. The filter cake is washed well with dichloromethane and the filtrate is concentrated to an amber oil. The crude oil is passed through a 50 g plug of silica gel (230-400 mesh), eluting with 20% acetone/hexane, while collecting 100 ml fractions. Fractions 1-3 are combined and concentrated to give 3.91 g (96%) of 4-t-Butyl-2-pyridine-carboxaldehyde as a light amber oil.

Aufarbeitung

  1. temperatureThe mixture is cooled
  2. filtrationis filtered through celite
  3. washThe filter cake is washed well with dichloromethane
  4. concentrationthe filtrate is concentrated to an amber oil
  5. washeluting with 20% acetone/hexane
  6. customwhile collecting 100 ml fractions
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-6c88f4d3fac14f9bb4d9c84be07569bb
Quelldatensatz
uspto-grants-2000_03
Patentnummer
US06043248

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